Rosie O’Donnell provides an update on her weight loss journey during a TikTok video posted on Thursday, March 20. The Emmy Award winner shares that she has continued to lose weight since starting Mounjaro, a prescription medication approved by the FDA for individuals with type 2 diabetes. Mounjaro, also known as Zepbound, contains tirzepatide and is effective for weight loss by reducing appetite and enhancing the body’s metabolism of sugar and fat. Similar to medications Ozempic and Wegovy, Mounjaro impacts satiety in the brain and is popular in Hollywood for weight loss. Rosie expresses her surprise at fitting into smaller clothes after shedding weight and reveals her positive lifestyle changes, including cooking for herself and her child in Ireland, where she recently moved. She credits her weight loss to the combination of medication, reduced sugar intake, increased physical activity, and improved sleep. Rosie’s determination to maintain a healthier lifestyle shines through as she shares her journey with her followers.