A recent trial suggests that a 5-day fasting-mimicking diet could enhance blood sugar management in individuals with type 2 diabetes. Image credit: mrs/Getty Images. This article was first published on Medical News Today. Dietary adjustments are vital in the treatment of type 2 diabetes and may even lead to disease remission. Fasting diets, which involve calorie restriction for set periods, have been proven to be effective in easing type 2 diabetes symptoms. Previous research has shown that a monthly cycle of a fasting-mimicking diet, restricting calorie intake for five consecutive days, can reduce blood sugar levels and lessen the need for medications. New evidence from a recent study supports the beneficial effects of a 5-day fasting-mimicking diet in real-world scenarios, outside clinical trials. In 2021, around 11% of Americans had diabetes, mostly type 2 diabetes. Fasting diets, which alternate between fasting and eating periods, offer symptom relief for type 2 diabetes and may be easier to sustain than long-term calorie reduction. A recent real-world study revealed that individuals with type 2 diabetes who followed a fasting diet involving restricted energy intake for five days per month experienced improvements in blood sugar levels, weight loss, and a reduced reliance on diabetes medications. This fasting program has been patented by L-Nutra, a nutrient technology company. William Hsu, MD, an endocrinologist and Chief Medical Officer at L-Nutra, highlighted the effectiveness of the fasting-mimicking diet when combined with medical supervision and registered dietitian coaching for managing type 2 diabetes in real-world settings. The study results were presented at the American Diabetes Association’s 85th Scientific Sessions on June 20, 2025, and are awaiting publication in a peer-reviewed journal. Lifestyle changes and medications are typically part of type 2 diabetes treatment. While medications manage symptoms, only lifestyle changes, like dietary adjustments, can lead to remission. Studies indicate that restricting daily calorie intake can effectively control blood sugar levels and aid weight loss in type 2 diabetes patients. However, maintaining such a diet long term is challenging, as prolonged calorie restriction can slow metabolism, making sustained weight loss difficult. Fasting diets, involving intermittent fasting or specific fasting days, are easier to follow and may alleviate diabetes symptoms. Fasting promotes cellular and body stress responses, aiding healthy aging by reducing inflammation and oxidative damage while boosting metabolism.
A type of intermittent fasting known as the fasting-mimicking diet involves reduced calorie intake for 4 to 7 consecutive days per month. Unlike traditional water-only fasting, this diet allows for a limited calorie intake, making it easier to follow. Research has shown that a 5-day fasting approach can have benefits for blood sugar control. By consuming a patented low-calorie, plant-based diet rich in healthy fats and fiber, individuals may experience improvements in blood sugar and insulin levels.
Recent studies have demonstrated that combining a 5-day fasting-mimicking diet with medications can be more effective in managing blood glucose levels compared to medications alone. These results were observed in controlled clinical trials, prompting a need to evaluate the real-world impact of this intervention. In a study evaluating the integration of a fasting-mimicking diet into routine care for individuals with type 2 diabetes, researchers found positive outcomes such as weight loss and reduced blood glucose levels.
Participants in the program reported being able to incorporate the fasting-mimicking diet into their daily lives with minimal disruption. However, it’s important for individuals with type 2 diabetes to consult with a healthcare provider before starting such a diet. While the benefits of the fasting-mimicking diet are promising, there are potential side effects such as fatigue and nausea that should be considered.
Einstein stated, “Although these symptoms improved between cycles, they could be risky for some individuals, particularly those with underlying health issues or frailty.” Hsu also warned, “While the program is suitable for most people with type 2 diabetes or metabolic syndrome, certain conditions like recent heart issues, advanced diabetes complications, frailty, a BMI below 18, or allergies to FMD ingredients may exclude individuals. The program emphasizes safety while aiming to provide innovative nutrition-focused care for metabolic health.” Lastly, Routhenstein suggested that “the addition of lifestyle guidance along with the option to seek advice from a dietitian may have impacted some of the study results.” Read the full article on Medical News Today.
