Researchers at Universitat Autònoma de Barcelona have demonstrated that enhancing the presence of the Klotho protein in mice results in increased lifespan, improved muscle and bone health, as well as enhanced brain function. Aging is often accompanied by undesirable changes such as muscle and bone mass loss, leading to weakness, frailty, and a higher susceptibility to falls. Additionally, the brain undergoes changes with neurons breaking down and diseases like Alzheimer’s becoming more prevalent.
The study led by Professor Miguel Chillón, published in Molecular Therapy, reveals that boosting the Klotho protein can help mice age more gracefully. The treated mice exhibited longer lifespans and overall better physical and mental health. Klotho, known for its anti-inflammatory and antioxidant properties, was specifically studied in its secreted form, s-KL, which circulates freely in the body without interfering with other systems like calcium metabolism.
To introduce s-KL into the mice, the researchers utilized a gene therapy approach involving adeno-associated viruses (AAV9) to deliver the genetic information for s-KL into the cells. This method was administered through both bloodstream and direct brain injections to ensure targeted delivery to key areas related to muscle and memory.
Mice were treated at different stages of life, with significant results observed by the time they reached the equivalent of around 70 human years. Those treated with s-KL lived 15–20% longer on average and exhibited increased muscle mass, stronger bones, and improved cognitive function compared to the control group.
The study also highlighted the benefits of s-KL on muscle and bone health. Treated mice maintained muscle strength, displayed larger muscle fibers, and showed reduced fibrosis, indicating less tissue damage. The protein boosted satellite cell activity, aiding in muscle repair and promoting physical activity. Furthermore, bone health, particularly in female mice, was enhanced with preserved bone structure, potentially offering protection against osteoporosis.
The findings suggest that enhancing the Klotho protein could be a promising avenue for supporting healthy aging and mitigating age-related declines in muscle, bone, and brain function.
Improvement in physical fitness was observed in subjects receiving treatment, with a decrease in muscle fibrosis and an increase in muscular regenerative capacity noted by researchers. Additionally, higher levels of s-KL were found to benefit the brain. As individuals age, neurons stop regenerating and brain plasticity declines, leading to weaker memory and an increased risk of diseases such as Alzheimer’s and Parkinson’s. The malfunctioning of support cells in the brain, known as glial cells, can contribute to inflammation and stress in brain tissue.
In a study involving naturally aged animals, physical tests and histological analysis of muscle tissue showed promising results in the treated group. The treated mice exhibited increased formation of new neurons in the hippocampus, the brain’s memory center, as well as heightened immune activity, particularly in processes related to phagocytosis, which helps clean up damaged or toxic materials in the brain.
The study’s lead author, Joan Roig-Soriano, highlighted the significance of these findings and the potential for transferring this therapy to humans using viral vectors administered intravenously. Transcriptomic analysis revealed elevated signals related to immune response and brain cell regeneration, suggesting that s-KL could protect brain health even before disease onset.
While the focus of the study was on mice, the implications could extend beyond the laboratory. The research team has filed patents covering various uses of Klotho, including cognitive support, bone and muscle strength enhancement, and lifespan extension. The goal is not just to increase lifespan but to enhance health span – the years of good health experienced.
The researchers emphasized that gene therapy may not be the sole option, as direct delivery of s-KL as a drug could also be effective. However, a reliable method for targeted delivery without adverse effects is still needed. Unlike other forms of Klotho that have shown side effects, s-KL appears to be safer while providing extensive benefits.
The study’s results hold promise for improving quality of life and addressing the challenges posed by an aging population. By developing interventions to slow or prevent age-related issues proactively, science may offer new approaches to aging. Klotho could be a valuable tool in this endeavor, offering benefits for muscle and bone health.
By stimulating our hearts, bodies, and minds simultaneously, this innovation could pave the way for a future in which aging no longer signifies deterioration. Please note that the article mentioned above is from The Brighter Side of News. Interested in more uplifting stories like this? Subscribe to The Brighter Side of News newsletter.
