A recent study suggests that obesity and stress may increase the risk of a particularly aggressive form of cancer. Researchers at the University of California Los Angeles discovered that certain stress-related neurotransmitters and obesity-related hormones can activate a protein called CREB, which promotes the growth of cancer cells in the pancreas. Mice fed a high-fat diet were more likely to develop precancerous lesions, and when stress levels were heightened through social isolation, the lesions grew further. The study found that female mice were at a higher risk for stress-related cancer development.
The researchers proposed exploring the use of existing medications to reduce the risk of obesity- and stress-related cancers. Beta-blockers, commonly prescribed for high blood pressure, were suggested as a potential treatment option due to their role in inhibiting stress-related cancer growth through β-adrenergic receptors.
Pancreatic cancer is known to have a low survival rate in the U.S., with patients often diagnosed at an advanced stage when treatment options are limited. The study underscores the importance of the connection between mental and physical health in cancer development. Stress and obesity can exacerbate disease progression, impacting a patient’s response to treatment. Maintaining a heart-healthy diet, moderate eating habits, regular exercise, and mindfulness were recommended strategies to reduce cancer risk and improve overall wellness.
While there have been advancements in chemotherapy and surgical techniques for treating pancreatic cancer, there is still a need for effective early screening tools and prevention strategies. Emphasizing the significance of lifestyle factors in cancer prevention and treatment, the study highlights the critical role of managing stress, maintaining a healthy weight, and engaging in physical and mental well-being activities.
“There has not yet been a breakthrough,” stated the oncologist. “While immunotherapies have been groundbreaking in other cancers, they have not shown the same potential in pancreatic cancer.” The doctor also emphasized the importance of spending time outdoors for improving mental and physical well-being, encouraging patients to stay active, connect with nature, and prioritize their overall wellness. “The main challenge lies in supporting patients who are not eligible for surgery, as surgery is still the most effective treatment option.” Fox News Digital contacted the study researchers for further comment. [Source: Deadly cancer type associated with obesity and high stress levels]
