In March 2025, Amy Schumer was candid about her health journey in New York City. The actress and comedian, 43, shared in an Instagram video on March 21 about her experience with hormone replacement therapy for perimenopause and using weight-loss medication.
Schumer disclosed that she turned to telehealth company Midi Health for help with her perimenopause symptoms and found relief with estrogen and progesterone. Perimenopause, the transitional period before menopause, can bring symptoms like hot flashes and irregular periods due to decreasing estrogen levels.
Thanks to hormone replacement therapy, Schumer reported improvements in her symptoms, including fuller hair, better skin, increased energy, and a revived interest in intimacy.
Additionally, Schumer mentioned her positive response to the medication Mounjaro, contrasting it with a previous negative experience with a similar GLP-1 drug. Despite the lack of insurance coverage for non-diabetes or obesity uses, she humorously addressed misconceptions about her health on the internet.
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