Physicians Utilize GLP-1s for PCOS Treatment—Here’s How Women’s Health Magazine”Note: This article may contain affiliate links that support the publication.”In a short span of time, GLP-1s have gained significant recognition. Initially used for diabetes management, these medications became popular for their remarkable weight loss effects. With growing interest, healthcare providers explored the broader potential of GLP-1s beyond weight loss. Researchers are optimistic about their ability to address addiction and boost brain health. Now, a new horizon has emerged for these injections: treating polycystic ovarian syndrome (PCOS).Characterized by irregular menstrual cycles, metabolic dysfunction, excess facial hair, and acne, PCOS presents challenges in both diagnosis and treatment. Treatment approaches often involve birth control pills and targeted interventions for specific symptoms like acne. Weight loss is a common recommendation for individuals with PCOS, although it can be particularly challenging due to inherent metabolic factors.“Within the PCOS community, the lack of clear causes and the emphasis on weight loss have been longstanding issues,” notes Dr. Kerry Krauss, a practicing OB-GYN with PCOS. “Our metabolic complexities make weight loss a daunting task, even more so than for the general population.”Meet the experts: Dr. Kerry Krauss, a practicing OB-GYN and advisor at Natural Cycles, and Dr. Karen Tang, an OB-GYN and founder of Thrive Gynecology.Weight loss has shown benefits in managing specific PCOS symptoms, according to a 2024 review published in Annals of Internal Medicine. However, achieving weight loss can be especially challenging for those with this lesser-understood condition. Encouragingly, early studies suggest that GLP-1s may hold promise in alleviating PCOS symptoms. Here’s what experts are uncovering.GLP-1s may aid in weight loss for individuals with PCOS, potentially surpassing rates seen in the general population.For those unfamiliar, GLP-1s are a group of hormone-mimicking drugs that interact with receptors in the body to delay stomach emptying, enhance satiety, and lower blood sugar levels. Two variations, semaglutide and tirzepatide, have demonstrated weight loss benefits, with the latter targeting an additional receptor. Research indicates that tirzepatide (marketed as Mounjaro and Zepbound) led to a 10.1% reduction in body weight after six months, while semaglutide (sold as Ozempic, Wegovy, and Rybelsus) resulted in a 5.8% decrease over the same period, as per a 2024 JAMA Internal Medicine study.Dr. Krauss suggests that individuals with PCOS may experience even greater weight loss effects with GLP-1s. “Even at minimal doses, sometimes below the therapeutic threshold,
Dr. Krauss from Thrive Gynecology explains that individuals with PCOS who are overweight or obese may benefit from losing a certain percentage of body weight to help regulate hormone imbalances. This weight loss could potentially reduce the risk of diabetes and high cholesterol, common conditions in those with PCOS. Research supports the use of GLP-1s for weight loss, showing effectiveness in reducing BMI, triglycerides, waist circumference, and total testosterone in individuals with PCOS, as per a 2024 meta-analysis in the Journal of Diabetes and its Complications.
GLP-1s may also aid in regulating periods for those with PCOS. Dr. Krauss notes that irregular periods are a common symptom of PCOS, affecting about 75 to 85 percent of individuals with the condition. Irregular periods can be challenging to manage and may impact fertility. GLP-1s, through promoting weight loss, could potentially help regulate periods and improve fertility by addressing the hormonal imbalances associated with weight, as discussed in a 2020 article in The Journal of Clinical Endocrinology and Metabolism.
Furthermore, GLP-1s can help improve insulin resistance in individuals with PCOS. Dr. Tang explains that insulin resistance is prevalent in those with PCOS, and GLP-1s can target mechanisms involved in insulin resistance, such as delaying gastric emptying and glucagon secretion. While GLP-1s are not currently approved specifically for PCOS treatment, they have been beneficial in managing insulin resistance in women with PCOS, as highlighted in a 2022 review in the International Journal of Molecular Sciences.
Previously, metformin was commonly prescribed for PCOS management due to its effects on blood sugar and insulin levels. Although metformin is less commonly used now, the approach of using diabetes medications like GLP-1s for PCOS management remains relevant.
It is important to discuss with your doctor before considering GLP-1 therapy for PCOS, as these medications are currently prescribed off-label. Despite this, many individuals with PCOS also have coexisting conditions that GLP-1s are approved for, such as diabetes or obesity. Your doctor can provide guidance on potential side effects and whether GLP-1 therapy is suitable for you.
Dr. Krauss suggests reviewing the benefits, potential risks, and compatibility with your treatment plan to determine if it is suitable. Additionally, Jennifer Garner recommends a Retinol Eye Cream, while new athletic shoes can assist in achieving your cross-training objectives.
