Reviewed by Craig Primack, MD, FACP, FAAP, FOMA
Compounded semaglutide, a potential weight loss solution, is generating interest. However, with no FDA approval, its effectiveness remains unverified compared to FDA-approved options like Ozempic and Wegovy. This article examines the safety and efficacy of compounded semaglutide.
Defined as a modified medication, compounded semaglutide is formulated due to recent supply shortages of Ozempic and Wegovy. While similar in composition, compounded semaglutide lacks FDA endorsement, necessitating caution in its use.
Differentiating between compounded semaglutide and its approved counterparts, Ozempic and Wegovy, reveals key disparities in safety and availability. It is imperative to source compounded semaglutide from reputable entities to ensure product integrity.
Despite a lack of clinical trials, anecdotal evidence suggests positive outcomes with compounded semaglutide. However, comprehensive studies on Ozempic and Wegovy demonstrate semaglutide’s efficacy in weight management.
Research, such as a 2021 Novo Nordisk study on semaglutide, highlights its viability as a weight loss aid. Participants, including those without diabetes, experienced significant benefits when combined with lifestyle modifications.
In summary, while compounded semaglutide shows promise, its unverified status necessitates careful consideration and consultation with trusted providers before use.
Individuals who took semaglutide lost nearly 15% of their body weight, while those on a placebo lost around 2.5%. Recent studies support these findings and suggest additional benefits beyond weight loss. In a 2024 analysis funded by Novo Nordisk, nearly 18,000 participants with cardiovascular disease and overweight or obesity (but not diabetes) showed sustained weight loss over four years with semaglutide treatment, along with a 20% reduction in cardiovascular events. It is important to note that these trials specifically relate to branded semaglutide, and there are no official results for compounded semaglutide.
When it comes to safety, studies on Ozempic and Wegovy indicate that they are generally safe with mild to moderate side effects that tend to resolve over time. Compounded semaglutide is usually safe as well, but lacks clinical trial support. An important safety concern with compounded medications is that since they are not FDA-approved, they may not adhere to the same stringent safety standards as non-compounded alternatives.
To ensure safety, it is recommended to obtain compounded semaglutide from reputable sources that prioritize quality and transparency. Look for products produced in FDA-regulated facilities, sourced from reputable manufacturers, and tested for quality and consistency. When considering compounded semaglutide versus non-compounded options, it is essential to prioritize safety and efficacy.
The side effects of compounded semaglutide may vary depending on the source of the medication, but are generally similar to those of Ozempic and Wegovy. Common side effects may include nausea, vomiting, diarrhea, headache, constipation, and stomach pain. If you experience concerning side effects, it is important to consult your healthcare provider.
In conclusion, while compounded drugs serve a purpose during drug shortages, their effectiveness may vary. The FDA does not guarantee the effectiveness of compounded drugs, so caution is advised when considering compounded semaglutide for weight loss. Although it shares the same active ingredient as Ozempic and Wegovy, which have shown effectiveness in weight management, the efficacy of compounded semaglutide remains uncertain. Always prioritize safety and consult with your healthcare provider before starting any weight loss treatment.
Make sure to get your prescription for compounded semaglutide from a licensed healthcare professional and a reputable compounding pharmacy based in the US. Be wary of shady websites and pharmacies that may sell compounded semaglutide that is ineffective or unsafe. If the compounded semaglutide doesn’t seem to be working right away, don’t worry. It could take some time for your body to adjust to the medication and for you to start feeling its effects. It’s important to consult your prescribing healthcare provider for medical advice, especially if you’re still feeling hungry while on semaglutide.
Have you heard about tirzepatide, also known as Mounjaro and Zepbound? These are GLP-1 receptor agonists. Our blog post compares tirzepatide to semaglutide. This informative article was originally published on ForHers.com and shared by MediaFeed.org.
