Title: Unveiling the Origins of Cystic Fibrosis
Breathing disorders are prevalent in the United States, impacting a significant portion of the population. Conditions such as COPD affect about 7% of individuals, while asthma affects approximately 10%. Additionally, digestive disorders like GERD, acid reflux, Celiac disease, and IBS affect millions more. Cystic fibrosis stands out due to its unique ability to cause both respiratory and digestive issues. An estimated 40,000 individuals in the U.S. have been diagnosed with cystic fibrosis, though this number may be underestimated as some cases go undiagnosed, notes Dr. Ashwin Basavaraj, system chief of pulmonary medicine at NYC Health + Hospitals.
Cystic fibrosis, a progressive genetic disease, affects vital organs such as the lungs and pancreas. It leads to the accumulation of thick mucus in the airways, trapping bacteria and causing respiratory complications, inflammation, and infections. The disease also affects the release of digestive enzymes in the pancreas, leading to malnutrition and growth issues. Common symptoms include coughing with phlegm, shortness of breath, greasy stools, and susceptibility to infections. Treatment options involve bronchodilators, mucus-thinning medications, HFCWO devices, and pancreatic enzymes to aid in digestion and nutrient absorption. Additionally, there are FDA-approved CFTR modulator oral therapies available that target the root cause of cystic fibrosis by addressing specific mutations.
While there is no cure for cystic fibrosis, these therapies have proven beneficial for many individuals. However, approximately 10% of patients may not benefit from modulators due to their genetic mutations or other factors.
“It is crucial for individuals with cystic fibrosis to tolerate the treatment,” says Boyle. He emphasizes that many people living with CF are still eagerly awaiting their breakthrough, which is why efforts are urgently being made to ensure accessible treatments for them. This article was first published on USA TODAY: What is cystic fibrosis?
